Renato Perona began his sporting career just after World War II in amateur road races and also on the track of his hometown, Terni. Selected for the 1948 London Olympics, he and Ferdinando Terruzzi formed a close-knit tandem partnership that won the gold medal. The same year, Perona competed in the sprint at the Amsterdam Track Worlds Championships (the tandem was not still included in the Worlds), but without much success. Perona raced until the end of the 1950s in six-days races and in international Grand Prix events, winning 47 times on the track.