A Uruguayan footballer, Ángel Romano was at his best in the 1910s and early 1920s, retiring from the national team in 1927. Although primarily a striker, he often was placed at left wing where he could display all his sublime collection of body fakes, sudden spurts, and dangerous cross kicks. Romano dèbuted with Nacional Montevideo in 1910, then moved to Peñarol and then played one year in Argentina, with Boca Juniors, along with compatriot Carlos Scarone. Returning to Nacional in 1915, Romano stayed there for 15 years, scoring 164 goals in 388 matches, and winning eight Uruguayan national titles.
Romano achieved his maximum glory with the Uruguayan National Team. From 1911-27 he won 68 caps, scoring 28 goals. He won a gold medal at the 1924 Paris Olympics and at six editions of the Copa America (1916-17, 1920, 1923-24, 1926), an all-time record. He also won the Copa Lipton five times between 1911-23 and had four wins at the Copa Newton between 1912-20.